Free Organic Chemistry of Drug Degradation RSC (Drug Discovery)

Download Organic Chemistry of Drug Degradation RSC (Drug Discovery)

Download Organic Chemistry of Drug Degradation RSC (Drug Discovery)

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The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identification of drug degradants and understanding of drug degradation mechanisms and pathways. This book is written by a veteran of the pharmaceutical industry who has first-hand experience in drug design and development, drug degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which should aid greatly in the efforts of degradant identification, formulation development, analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation will first be reviewed and then illustrated by examples of drug degradation reported in the literature. The author brings the book to a close with a final chapter dedicated to the strategy for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is Chapter 3, Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex one. This chapter employs more than sixty drug degradation case studies with in-depth discussion in regard to their unique degradation pathways. With the increasing regulatory requirements on the quality and safety of pharmaceutical products, in particular with regard to drug impurities and degradants, the book will be an invaluable resource for pharmaceutical and analytical scientists who engage in formulation development, analytical development, stability studies, degradant identification, and support of manufacturing process improvement. In addition, it will also be helpful to scientists engaged in drug discovery and development as well as in drug metabolism studies. The Pharmaceutical Industry and the Future of Drug It is not only the inevitable loss of market share from generic companies that the innovating company must be concerned about Once a candidate drug is patented many Wiley: Solid State Chemistry and its Applications 2nd Solid State Chemistry and its Applications 2nd Edition: Student Edition is an extensive update and sequel to the bestselling textbook Basic Solid State Chemistry pH-Sensitive nano-systems for drug delivery in cancer therapy Abstract Nanotechnology has been widely used in the development of new strategies for drug delivery and cancer therapy Compared to traditional drug delivery systems core journals in CAplus - Chemical Abstracts Service CAplus Core Journal Coverage List Bibliographic information and abstracts for all articles in more than 1500 key scientific journals are added to CAplus SM Journal Rankings on Environmental Chemistry International Scientific Journal & Country Ranking Display only Open Access Journals Display only SciELO Journals (In Progress) European Journal of Chemistry European Journal of Chemistry accepts original research and review papers as well as letters in all areas of chemistry A manuscript submitted to the journal for Nanotechnology in Drug Delivery and Tissue Engineering The application of nanotechnology in medicine referred to as nanomedicine is offering numerous exciting possibilities in healthcare Herein we discuss two Artemisinin Resistance in Plasmodium falciparum Malaria Original Article Artemisinin Resistance in Plasmodium falciparum Malaria Arjen M Dondorp MD Franois Nosten MD Poravuth Yi MD Debashish Das MD Visible-Light-Induced Degradation of Rhodamine B by Visible-light-induced photodegradation of rhodamine B over nanosized Bi 2 WO 6 has been observed Bi 2 WO 6 exhibited a high photoactivity to photodegrade rhodamine B Chemistry Journals - University of Cambridge Chemistry Journals Since 1995 this page has held one of the world's most comprehensive and up-to-date lists of internet-linked chemistry-related journals
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